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These changes accumulate with time affecting both intracellular and extracellular function and by engaging the receptor for advanced glycation end products (RAGE)

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Interestingly, overexpression of the transcription factor Krueppel-like factor 6 (KLF6) increases SLC7A11 expression and co-enzyme Q10 synthesis [93] while p53 increases GPX4 expression [98] , thereby, acting synergistically with NRF2

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